Invest Ophthalmol Vis Sci. 2012 May 17;53(6):2978-92. doi: 10.1167/iovs.11-8803.
Saad A., Gatinel D.
Abstract
PURPOSE:
To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas.
METHODS:
This study retrospectively reviewed the data of 220 eyes separated into three groups by the NIDEK Corneal Navigator System automated corneal classification software: normal (N) (n = 123); forme fruste keratoconus (N topography with contralateral KC) (n = 34); and KC (n = 63). Anterior corneal and ocular aberrations were obtained with the optical path difference scan and compared using a Kruskal-Wallis test. Evaluation of these data to discriminate between the three groups was assessed using a Receiver-Operating Characteristic curve analysis.
RESULTS:
Corneal and ocular tilt, vertical coma, and trefoil were significantly different in the FFKC as compared with the N group. The discriminant functions between the FFKC and the N group, and between the KC and the N group reached an area under the receiver operating characteristic curve of 0.98 and 0.96, respectively.
CONCLUSION:
Indices generated from corneal and ocular wavefront can identify very mild forms of ectasia that may be undetected by Placido-based neural network programs.
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